ATRX and neoplasm: Recently, large-scale genome sequencing efforts have identified ATRX mutations and deletions in a range of tumor types, including glioblastoma multiforme, neuroblastoma and pancreatic neuroendocrine tumors (Jiao et al. 2011; Schwartzentruber et al. 2012; Cheung et al. 2012; Molenaar et al. 2012; Clynes et al. 2013).