The expression of the first enzymes of the cholesterol/isoprenoid synthesis pathway (Mvd, Mvk, Pmvk, Fdps and Idi1) did differ in the total study set, but the post hoc test only confirmed significant downregulation of Mvd, Mvk and Hmgcr by KO compared to HF (Figure 2, “Mevalonate pathway” and, “Additional metabolic pathways”), while no, or less pronounced decreases were found with FO supplementation. The gene discussed is HMGCR; the disease is hydrops fetalis.