ACADS and hydrops fetalis: The expression of several genes involved in fatty acid metabolism were upregulated in the FO group, e.g. genes involved in uptake (Fatp-1) and β-oxidation of fatty acids (Vlacs, Acox1, Ehhadh, Hsd17b4, Acaa1b, Decr2, Ech1 and Peci in peroxisomes and Cpt1a, Cpt1b, Hadha, Acadvl, Acadm, Acads, Decr1 and Dci in mitochondria) (Figure 2, see “Peroxisomal pathways” and “Mitochondrial pathways”) compared to HF.