Finally, the iTRAQ analysis here suggests that there is an increase in the expression of the voltage-dependent anion channel 1 (VDAC-1) – a protein identified as linking parkin to defective mitochondria in PD [43,44] – after complete dopamine deafferentation of the striatum at 14 days post 6-OHDA lesioning (Table 3). This evidence concerns the gene PRKN and Parkinson disease.