The association of the MMP-1 (-1607 1G/2G) SNP and sepsis might be due to linkage disequilibrium with the MMP-13 SNP because the MMP-13 and MMP-1 genes are both located in the same cluster of the chromosome 11q22-23 along with the MMP-3, MMP-7, MMP-8, MMP-10, MMP-12, and MMP-20 genes. This evidence concerns the gene MMP12 and Sepsis.