Furthermore, loss of CADM1 expression was significantly associated with shorter survival in HR positive (both data sets p = 0.001 and p = 0.022, Figure 4), but did not have a prognostic relevance in HER2 positive patients, indicating a tumor suppressing effect of CADM1 in HER2 negative patients only (data not shown). This evidence concerns the gene ERBB2 and neoplasm.