SPARC, RECK, TNFAIP3 and CXCL14 were down-regulated (p < 0.05) in BCBM as compared to primary BC samples irrespectively of the cancer subtype, while for CADM1, this correlation was found in HR positive and TNBC samples (Figure 1B and Supplementary Figure 1). Here, SPARC is linked to breast cancer.