In conclusion, our study shows a down-regulation of CADM1, RECK, SPARC, CXCL14 and TNFAIP3 in brain metastases samples and especially implies CADM1 as an important prognostic factor, which is commonly lost in BC subtypes with poor outcome and refers to an increased risk of brain metastasis formation. The gene discussed is CADM1; the disease is breast cancer.