Initially it was demonstrated that ATM a well known tumor suppressor which belongs to the family of proteins related to phosphoinositide kinases, physically interacts with BRCA1 in irradiated cells [43,44], and that it specifically phosphorylates BRCA1 at serine residues 1423, 1524 and 1457 [43,44]. This evidence concerns the gene BRCA1 and neoplasm.