Upregulated:IGF2, MAD2L1, and CCNB1 in ACC compared to ACADownregulated: ABLIM1, NAV3, SEPT4, and RPRM in ACC compared to ACAA combination of IGF2 and Ki-67 has 96% sensitivity and 100% specificity in diagnosing ACC. This evidence concerns the gene SEPTIN4 and adrenal cortex carcinoma.