Upregulated: 2 ubiquitin-related genes (USP4 and UFD1L), insulin like growth factor-related genes (IGF2, IGF2R, IGFBP3 and IGFBP6 in ACC compared to ACADownregulated: cytokine gene (CXCL10), several genes related to cell metabolism (RARRES2, ALDH1A1, CYBRD1 and GSTA4), and the cadherin 2 gene (CDH2) in ACC compared to ACA. The gene discussed is IGFBP6; the disease is adrenal cortex carcinoma.