The eIF5A-1 isoform is expressed at high levels in all tissues, although the eIF5A-2 isoform is detectable only in some embryonic tissues, adult testis, central nervous system and cancer tissue (Clement et al., 2003; He et al., 2011; Jenkins et al., 2001; Zhu et al., 2011). The gene discussed is EIF5A2; the disease is cancer.