The DGKZ gene encodes diacylglycerol (DAG) kinase zeta, a member of the DAG kinase family which phosphorylates DAG to phosphatidic acid and plays important roles in lipid signaling implicated in neurological diseases, including epilepsy, depression and Alzheimer's disease [11] – [13]. The gene discussed is DGKZ; the disease is early-onset autosomal dominant Alzheimer disease.