SNPs affecting USF1 binding to the Pten promoter have been found to be associated with Cowden syndrome [64]; the loss of USF1 transcriptional activity has been described in several breast cancer cell lines [65] and the activation of the hTERT gene in oral tumors is associated with the decreased expression of USF1 and USF2 [66]. The gene discussed is USF1; the disease is breast cancer.