A recent study identified annexin A11 as a novelnon-HLA susceptibility locus for sarcoidosis.(6) Many other loci encoding TNF-α and co-stimulatory molecules onantigen-presenting cells such as CD80 and CD86, as well as the chemokine receptors CCR2and CCR5, have been found to increase susceptibility to sarcoidosis.(7). The gene discussed is TNF; the disease is sarcoidosis.