In the liver, Perilipin 2 (Plin2) is the most abundant lipid droplet protein; while Perilipin 3 (Plin3) is mildly expressed and Perilipin 1 (Plin1) is de novo expressed in non-alcoholic steatohepatitis [25]. This evidence concerns the gene PLIN2 and metabolic dysfunction-associated steatohepatitis.