The lack of hepatic steatosis and reduced hepatic triglyceride levels in Plin2KO mice result from multifactorial effects on cellular lipid homeostasis, namely, a downregulation of de novo lipogenic and triglyceride synthetic pathways and a lack of compensation for Plin2 by Plin1 and Plin3. Here, PLIN2 is linked to Hepatic steatosis.