TF and vascular hemostatic disease: However, which class of toxins accounts for most fibrinogen consumption in humans remains to be investigated, but we demonstrate herein that procoagulant enzymes and high TF plasma levels may exert a relevant role in the hemostatic disorder evoked by Bothrops bites, since intravascular thrombin generation, evidenced by raised plasma levels of TAT complex [52], [53], are noticed in patients.