AKT1 and neoplasm: [15]. EVO has been shown to exhibit anti-tumor properties by suppressing tumor growth [16], metastasis [17] and angiogenesis [18]. Furthermore, EVO can induce apoptosis by inhibiting nuclear factor kappa B (NF-κB) activation, leading to the downregulation of NF-κB-regulated gene products such as Cyclin D1, XIAP, Bcl-2, and Bcl-XL [19], [20]. The PI3K/Akt and ERK signaling pathways also play important roles in cancer cell apoptosis in responses to EVO [21]-[23].