PTGS2 and rheumatoid arthritis: Although physiological activity of iNOS and COX-2 may provide a definite benefit to the organism, aberrant or excessive expression of iNOS and/or COX-2 has been implicated in the pathogenesis of many disease processes, as septic shock, cardiomyopathy, acute and chronic neurodegenerative disease, rheumatoid arthritis, and carcinogenesis [8,9,10].