To further illustrate the roles of HDAC1/4/miR-200 in docetaxel-resistance of LAD patients, we evaluated the expression of HDAC1/4 in LAD tissues from patients who received docetaxel-based chemotherapies, and showed that the expression level of HDAC1/4 mRNA in docetaxel-sensitive LAD tissues was significantly lower than that in docetaxel-insensitive tissues. Here, HDAC1 is linked to leukocyte adhesion deficiency.