Murine studies have also demonstrated that FFAs can induce up-regulation of the p53 tumour suppression gene, expression of the TRAIL-receptor (TRAIL-R) [102] and increased levels of JNK [103–105]—an important regulator of apoptosis that has been shown to promote the development of NASH in mice [106]. Here, MAPK8 is linked to metabolic dysfunction-associated steatohepatitis.