ChIP experiments, using cell lysates harvested 1 hour after infection, confirmed the binding of GFI1 to both GFI1 binding sites in the MIE promoter, but not in the MIE coding region and showed that treatments promoting the upregulation of GFI1 by inhibiting H3K27 trimethylation increase the binding (Fig 3B Lower panel). This evidence concerns the gene GFI1 and infection.