A search for ion channels in the cancer profiling database, Oncomine, turns up CLIC1 as one of the most upregulated genes [166], and chloride current associated with increased CLIC1 expression is present in progenitor cells isolated from human glioblastomas, and is responsible for promoting proliferation, clonogenicity, and tumorigenic capacity [167]. The gene discussed is CLIC1; the disease is cancer.