Although we could not observe any superiority of NSG-HLA-A2/HHD over NSG-mice with regard to overall engraftment and T cell development, we further explored this mouse strain, as these mice were recently shown to enable HLA-I restricted T cell responses after transplantation of human CB-HSPC [19] and should enable the investigation of human CD8 T cell responses against human, autologous cancers of HLA-A2+ patients. Here, CD8A is linked to cancer.