When PTEN and APE1 are considered together, patients with tumours that exhibit high PTEN and low APE1 mRNA expression have a significantly better prognosis compared to tumours that have low PTEN/high APE1 mRNA expression or low PTEN/low APE1 mRNA expression or high PTEN/high APE1 mRNA expression (Figure 1C). This evidence concerns the gene PTEN and neoplasm.