This included several repair factors that have previously been implicated in PTEN deficiency, including RAD51 [21, 24, 37], MRE11 [22], and the RAD51 paralogs RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 [38]. The gene discussed is XRCC2; the disease is hyperinsulinemic hypoglycemia, familial, 4.