Such a translational approach between preclinical and clinical data will continue to support the development of the MAGE-A3 immunotherapy, which is now under evaluation in two large, double blind, randomized phase III trials for the treatment of NSCLC (MAGRIT, NCT00480025) and melanoma (DERMA, NCT00796445). This evidence concerns the gene MAGEA3 and non-small cell lung carcinoma.