mRNAs encoding 4 of the 8 exocyst complex subunits (sec3, sec8, sec10, and sec15) have CPE sequences in their 3′ UTRs, and their localization and/or translation could be regulated by orb2. Another possible orb2 regulatory target in cyst polarization is cdc42. This small membrane anchored GTPase directs exocyst complex localization during ciliogenesis in kidney epithelial cells, interacting directly with Sec10 [36], [37]. Here, EXOC5 is linked to cyst.