Gosmanov et al. [6] showed that patients with ketosis-prone diabetes displayed a pattern of insulin secretion similar to that of patients with ketosis-resistant T2DM and obese nondiabetic subjects after hyperglycemia remission, but other researches have reported that non-insulin-dependent ketosis-prone T2DM showed lower C-peptide than that of typical T2DM after correction of hyperglycemia and ketosis [4]. This evidence concerns the gene INS and diabetes mellitus.