CASS4 is a relatively understudied gene as evidenced by a mere three publications returned in a PubMed search for the gene and its alias, HEPL. The reported GWAS significant SNP, CASS4/rs7274581, is protective against AD, and a SNP in LD with this GWAS SNP, CASS4/rs6024870, shows evidence of regulatory function as well [Rosenthal, unpublished data]. Here, CASS4 is linked to Alzheimer disease.