Hypoxia-inducible transcription factor-1 (HIF-1α) is overexpressed in MM cells within the hypoxic microenvironment and then HIF-1α inhibition by a lentivirus short hairpin RNA pool showed that HIF inhibition blocks MM-induced angiogenesis and reduces MM tumor burden and bone destruction in vivo, supporting HIF-1α as a potential therapeutic target in MM [55]. This evidence concerns the gene HIF1A and neoplasm.