A widely popular definition of the endothelial dysfunction includes overexpressing adhesion molecules such as ICAM-1, VCAM-1, E-selectin, and P-selectin in the vascular endothelium as well as physiological changes such as flow-mediated vasodilatation (FMD) or forearm blood flow (FBF). The gene discussed is SELE; the disease is endothelial dysfunction.