Tumor stem cells in oral and maxillofacial SCC, such as vascular endothelial growth factor (VEGF), phosphatase and tensin homolog (PTEN), matrix metallopeptidase-9 (MMP-9), tissue inhibitor of metalloproteinase-2 (TIMP-2), CD44 and CD133, have been potential markers (3) by exerting corresponding effects on the occurrence and suppression of tumors or lymphatic metastasis. This evidence concerns the gene TIMP2 and neoplasm.