ITGAX and neoplasm: Based on our previous experiments in which VSSP inoculation in vivo promoted differentiation of adoptively transferred tumor-induced MDSCs to DCs and not to macrophages [24], we focused our analysis particularly on differentiation towards CD11c+ DCs in vitro. A more than 2 fold increase was detected in both, percentage and mean fluorescence intensity (MFI) of CD11c+ cells, within EL4-induced MDSCs treated in vitro with VSSP (p = 0.001 and p = 0.002, respectively) (Figure 5A and B).