Monoclonal antibodies are now widely utilized in the treatment of a number of tumor types; pertinent examples including trastuzumab (anti-Her-2) for the treatment of breast cancer, rituximab (anti-CD20) for the treatment of lymphoma, and the recently approved immunoconjugate T-DM1, which fuses trastuzumab to a highly potent chemotherapy, emtansine (DM1 [deacetyl maytansine]) to facilitate local delivery and minimize systemic toxicity [21]. This evidence concerns the gene ERBB2 and breast carcinoma.