Treatment of mice bearing Lewis Lung Carcinoma tumors with a small molecule inhibitor of CSF-1R (GW2580: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine) inhibited the recruitment of CD11b+Gr1loLy6Chi monocytic MDSC into tumors and reduced the expression of pro-angiogenic and immunosuppressive genes within the tumor microenvironment [46]. Here, ITGAM is linked to neoplasm.