In addition, a recent study showed that blocking IL-6R, a key receptor to a cytokine that is associated with suppression of the cytotoxic immune response, may also lead to decreases in accumulation of monocytic and granulocytic MDSC, reduction in tumor growth and improvement in T-cell function in squamous cell carcinoma of the skin (CMC-1 cells) bearing tumor bearing mice (all compared to control tumor bearing animals). This evidence concerns the gene IL6R and neoplasm.