Over 20 vaccine immunotherapy clinical trials are currently ongoing in various stages of completion (http://clinicaltrials.gov) examining varying iterations of the above approaches for cancers including but not limited to PC, including novel peptides (e.g., mesothelin, VEGFR1/VEGFR2 and survivin), DNA-based vaccines, and combinations of vaccines with chemotherapy. The gene discussed is FLT1; the disease is cancer.