It is regulated by CCAAT/enhancer binding protein (C/EBP) α and peroxisome proliferator-activated receptor (PPAR)-γ in the phosphatidyl inositol 3-kinase (PI-3 K) and mitogen-activated protein kinase (MAPK) pathways, inhibited the role of insulin in glucose uptake and impaired glucose tolerance (37). Here, INS is linked to Impaired glucose tolerance.