NF-κB induces the production of local and systemic inflammatory mediators (such as TGF-b, Fas ligand, TNF-a, leptin, adiponectin, IL-6, IL-1b, IL-8) (Table 1) involved in different lesions of NASH such as activation of Kupffer cells and macrophages, apoptosis, and inflammation. This evidence concerns the gene IL6 and metabolic dysfunction-associated steatohepatitis.