Irrespective of viral hepatitis, the risk factors for elevation of serum ALT levels include; male gender (27-29, 31), age (24), obesity (25-31), diabetes (25, 28, 30, 31), hyperlipidemia (24, 25, 28, 30, 31), moderate to heavy alcohol drinking (26, 29, 31), and drug-induced liver injury (DILI) (32, 33). This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.