On the basis of HBV antibody profile, OHBS may be distinguished as: seropositive-OHBS (anti-HBc and/or anti-HBs positive) and Seronegative-OHBS (anti-HBc and anti-HBs negative) (4).The clinical relevance of OHBS has not been investigated extensively; however, several studies have suggested a potential association between OHBS and increased risk of cirrhosis and hepatocellular carcinoma (HCC). This evidence concerns the gene KRT88P and Cirrhosis.