SSBP2 and hepatocellular carcinoma: After crossing that list with the list of frequently methylated genes we identified using methylation arrays, we chose three genes for validation, one gene that was already found to be hypermethylated in HCC by several groups (RASSF1A) and two genes that we have reported as methylated in other tumors but not in HCC (B4GALT1 and SSBP2).