Epigenetic lesions in DNA without mutations in the coding regions have been shown to be common phenomena in the pathogenesis of a wide range of cancers, especially the methylation-mediated silencing of tumor suppressor genes such as VHL, p16INK4a, E-cadherin, hMLH1, BRCA1, and LKB1 [25, 26]. Here, CDKN2A is linked to cancer.