Studies in adults showed that patients with mild disease had higher numbers of NK cells, with the majority of cells having increased expression of activation markers (CD69, CD38, and HLA-DR), adhesion molecules (CD11a and CD44) (Table 1), and markers of intracellular cytotoxic granules (TIA-1), in contrast to severe dengue where reduced NK cell numbers were observed (31). Here, ITGAL is linked to dengue disease.