We further investigated whether expression of GM3 synthase in the present model of human colon cancer HCT116 cells is induced by the use of other chemotherapeutic agents (5-Fluorouracil and Doxorubicin) which are well- known to induce apoptosis of various human cancer cells as well as colon cancer cells. This evidence concerns the gene ST3GAL5 and malignant colon neoplasm.