SOX2 and adrenal cortex carcinoma: Univariate analysis based on clinicopathological features showed that T classification (OS, p < 0.001; DFS, p < 0.001), distant metastasis (OS, p < 0.001; DFS, p < 0.001), nerve invasion (OS, p = 0.025; DFS, p = 0.029), and SOX2 expression (OS, p < 0.001; DFS, p < 0.001) were significant risk factors affecting OS and DFS of 131 ACC patients (Table 2).