Further understanding of PC development may elucidate etiologies and predict potential treatment strategies for neuronal migration disorders such as Lissencephaly and Zellweger syndrome (Hatten 1999) as well as in Reelin signaling-involved neurodegenerative diseases such as Alzheimer’s disease (Krstic et al. 2013). This evidence concerns the gene RELN and pachyonychia congenita.