We modeled the associations between UA and (i) demographic, anthropometric and other variables previously reported to be associated with serum UA (referred to as conventional variables); (ii) the presence of metabolic syndrome (MS) and the levels of MS components and (iii) selected genetic variants in the SLC2A9, ABCG2 and MTHFR genes. The gene discussed is MTHFR; the disease is myeloid sarcoma.