During the past ten years, three dominant mutations in TMC1 (p.D572N, p.D572H and p.G417R) from four DFNA36 hearing loss families have been reported [5], [14], [18], [19], i.e., the mutation of p.D572N and p.D572H were found in North American families [5], [18], [19]. The gene discussed is TMC1; the disease is hearing loss disorder.