Using a murine model for invasive Salmonellosis, we have recently reported on the antigen-independent production of IFN-γ by memory CD8+ T cells through a complex in vivo mechanism that involves intracellular sensing of flagellin by NLRC4 inflammasomes, which is an important contributor to protection against invasive murine Salmonellosis [3]. The gene discussed is CD8A; the disease is salmonellosis.