CCN2 and diabetes mellitus: Importantly, however, altered expression of individual genes that might associate with a diabetes-induced pro-inflammatory state was observed in the present model, including RAGE ligand s100A6[49], Txnip[50], Fas, C4a[51], CD55[52], and Gbp-8[53]), as well as with glomerulosclerosis and tubulointerstitial fibrosis (Ctgf; [54], [55]).