Therefore, we used the EMBL-EBI Expression Atlas (http://www.ebi.ac.uk/gxa/) to query the direction of expression of each corresponding human gene (CDKN1A, CCND1, MDM2, TIMP3, MYC, BTC, OBFC2A, and THBD) in the malignancy signature derived from these annotation terms across a panel of human cancer-based expression profiles. This evidence concerns the gene TIMP3 and cancer.