Notably, unlike the overall change pattern of circulating adiponectin, the serum concentrations of CTRP1 were significantly higher in subjects with T2DM in both sexes than that in control subjects (378.3±43.9 ng/ml vs. 135.6±15.4 ng/ml in men and 304.4±30.4 ng/ml vs. 149.8±12.7 ng/ml in women, T2DM vs. Control; age and sex-adjusted p<0.01) (Table 1 & Figure 1B). Here, C1QTNF1 is linked to type 2 diabetes mellitus.