ADIPOQ and type 2 diabetes mellitus: Our data showed a significant increase of circulating CTRP1 in T2DM patients compared with healthy subjects (Figure 1B), which is opposite to the decreasing trend of serum adiponectin observed in the same population, suggesting that even though both CTRP1 and adiponectin are from the same CTRP family, their clinical characteristics in diseases like T2DM may not be necessarily identical.