TNF and Granuloma: It is supposed that, in sarcoidosis, granulomas may be caused by a series of factors, including Th1 cell activation by antigen-presenting cells (APC) and their cytokine release (IL2 and interferon-gamma) with a subsequent inflammatory cell recruitment and tissue infiltration; in addition, T lymphocytes and macrophages are responsible for an overproduction of TNF-alpha, amplifying the granulomatous reaction [6].