Compared with individuals with COX-2 -765 GG genotype, individual with GC or GC/CC genotypes both had a significantly increased susceptibility to breast cancer (OR = 1.55, 95% CI = 1.09–2.00 and OR = 1.56, 95% CI = 1.11–2.21, respectively). The gene discussed is PTGS2; the disease is breast cancer.