Other associated loci included the TCR beta-gene a partner of TCRα; TNFSF4 (also called OX40L) a costimulatory receptor for T-cell activation involved in Lupus [158], Crohn’s disease [159], rheumatoid arthritis [160], and celiac disease; Cathepsin H, an enzyme likely involved in antigen processing and associated with Type 1 diabetes [161]; ZNF365, a transcription factor associated with inflammatory bowel disease (IBD) [159] and atopic dermatitis [162]; IL10RB-IFNAR1, a region associated with IBD [163]. The gene discussed is IL10RB; the disease is inflammatory bowel disease.