Although we did not observe differences in brain EETs levels in mice fed a high fat diet, sEH inhibition could still be more protective in type 2 diabetic mice than control mice because it could increase EETs in tissues other than the brain, especially the pancreas, which as previously reported by Luria et al. [39], would improve beta cell survival, insulin secretion and glycemic status. Here, EPHX2 is linked to type 2 diabetes mellitus.