As the extracellular domain of Trop-2 contains four putative N-glycosylation sites [5], we generated an entirely deglycosylated Trop-2 variant through site-directed mutagenesis of the N-glycosylation sites to Ala (manuscript in preparation), and expressed this Trop-2 variant in colon cancer cells. Here, TACSTD2 is linked to malignant colon neoplasm.